trokendi xr approved for migraine treatment

Clinical Data

Trokendi XR® delivers the efficacy you’d expect with QD dosing for steady, 24-hour migraine prevention1,2

Trokendi XR has a slow rate of rise and low peak-to-trough fluctuation vs Topamax® (topiramate)1,2

trokendi xr vs Topamax clinical study results
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Study design1

  • A phase 1, single-center, multiple-dose, single-blind, randomized, crossover, pharmacokinetic (PK) study of Trokendi XR (200 mg once daily) and Topamax (100 mg twice daily) in 39 healthy adults
  • Subjects were titrated to a 200 mg/day dose of either Trokendi XR or Topamax over a period of 3 weeks
  • Following titration, subjects were maintained on 200 mg/day for 10 days
  • Following a 32-day washout period, subjects crossed over to alternate treatment

Primary endpoint1

  • Relative bioavailability of Trokendi XR and Topamax at steady-state

Once-daily Trokendi XR was designed and approved to be written QD3

trokendi xr vs Topamax dosage simulation
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What role can patient preference play in migraine prevention therapy?

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